A few links between taking Tylenol while pregnant and autism.

If you ignore the advice and autism continues... pharma is happy. If you ignore the advice and continue taking drugs...pharma is happy. Pharma would prefer you ignored it on balance.

Paracetamol (N-acetyl-p-aminophenol (APAP), otherwise known as acetaminophen) is the active ingredient in more than 600 medications used to relieve mild to moderate pain and reduce fever. APAP is widely used by pregnant women as governmental agencies, including the FDA and EMA, have long considered APAP appropriate for use during pregnancy when used as directed. However, increasing experimental and epidemiological research suggests that prenatal exposure to APAP might alter fetal development, which could increase the risks of some neurodevelopmental, reproductive and urogenital disorders. Here we summarize this evidence and call for precautionary action through a focused research effort and by increasing awareness among health professionals and pregnant women. APAP is an important medication and alternatives for treatment of high fever and severe pain are limited. We recommend that pregnant women should be cautioned at the beginning of pregnancy to: forego APAP unless its use is medically indicated; consult with a physician or pharmacist if they are uncertain whether use is indicated and before using on a long-term basis; and minimize exposure by using the lowest effective dose for the shortest possible time. We suggest specific actions to implement these recommendations. This Consensus Statement reflects our concerns and is currently supported by 91 scientists, clinicians and public health professionals from across the globe.’

Paracetamol is commonly used to treat fever and pain in pregnant women, but there are growing concerns that this may cause attention deficit hyperactivity disorder and autism spectrum disorder in the offspring. A growing number of epidemiological studies suggests that relative risks for these disorders increase by an average of about 25% following intrauterine paracetamol exposure. The data analyzed point to a dose-effect relationship but cannot fully account for unmeasured confounders, notably indication and genetic transmission. Only few experimental investigations have addressed this issue. Altered behavior has been demonstrated in offspring of paracetamol-gavaged pregnant rats, and paracetamol given at or prior to day 10 of life to newborn mice resulted in altered locomotor activity in response to a novel home environment in adulthood and blunted the analgesic effect of paracetamol given to adult animals. The molecular mechanisms that might mediate these effects are unknown. Paracetamol has diverse pharmacologic actions. It reduces prostaglandin formation via competitive inhibition of the peroxidase moiety of prostaglandin H2 synthase, while its metabolite N-arachidonoyl-phenolamine activates transient vanilloid-subtype 1 receptors and interferes with cannabinoid receptor signaling. The metabolite N-acetyl-p-benzo-quinone-imine, which is pivotal for liver damage after overdosing, exerts oxidative stress and depletes glutathione in the brain already at dosages below the hepatic toxicity threshold. Given the widespread use of paracetamol during pregnancy and the lack of safe alternatives, its impact on the developing brain deserves further investigation.’

‘Paracetamol is used by more than 50% of women worldwide during pregnancy; headache representing the most frequent indication. Several studies report that long-term exposure to paracetamol in utero is associated with adverse neurodevelopmental outcomes in children, indicating a dose-response effect. However, less or no risk is found to be associated with short-term exposure. Paracetamol most likely crosses the placenta through passive diffusion, and there are several possible mechanisms for how paracetamol might affect fetal brain development.’

RFK was far more powerful before he was in power. By tempting him into office he was been successfully neutered, hamstrung and compromised. Vaccine and pesticide safety have been forgotten for hysteria about seed oils and pasteurised milk (though consuming any kind of milk post-weening, especially from another species is harmful). RFK’s been given the soft token gesture of paracetamol because it’s not under patent, doesn’t belong to a pharma company, it’s cheap, they can’t make much money out of it, the warning only applies to pregnant women and people will continue to pop it like sweets; though it stresses the liver and should only be taken sparingly.

Linking Tylenol with Trump and fascism works in pharma’s favour. They know all about creating a backlash and reverse psychology. They don’t make much money out of paracetamol, but autism makes them a bomb. The autism pharmaceutical market was worth $2.12 billion in 2020. It was apparently worth $3.78 billion in 2021. And in 2022 is was $6.94 billion. Expected to be $7.41 billion in 2024.

There may well be little appetite in parents of autistic children to know what may have caused it, and that it might have been prevented. Of course those with ASD can led productive lives, but many, though they are dearly loved, don’t.

There is also little appetite among researchers in ASD or in pharma, who make a bomb out of it, for finding the cause on which their careers and cash-cows were built, with the potential that they may well lose them if ASD is prevented.

However, I know what I would want to know if I were thinking of getting pregnant.

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